Water electrolysis has recently been developed as a compelling alternative to steam methane reforming (SMR) to produce hydrogen without emitting CO2. Its implementation for hydrogen production is foreseen to significantly reduce CO2 emissions resulting from SMR which accounts for 1.7% of global emissions to date. Amongst electrolysis technologies, the Anion Exchange Membrane Electrolyser (AEMEL) demonstrates potential advantages in ease the cell design, lower capital and operating expenditures. Nevertheless, AEMEL faces challenges due to its poor durability and low efficiency, which demands further research and innovation in Membrane-Electrode-Assembly (MEA) optimization and cell design. ENDURION’s main objective is to develop an efficient, durable, low-cost AEMEL through the synergistic approach of MEA materials development and novel cell design employing exclusively earth-abundant materials and up-scalable processing. This will be elaborated by integrating and merging the recent advances in materials science, modern characterisations and processing tools, as well as lab-scale developments of components of AEMEL cells. Systematic work on novel materials development of porous transport layer electrodes, Ni-based nanocrystals, ionic liquid electrocatalysts and bioresource membrane, along with novel AEMEL cell and stack design will be the main tasks. ENDURION is expected to demonstrate an innovative AEMEL with an improved HHV efficiency of more than 30%, a hundred times higher H2 purity, and almost three times higher membrane conductivity than state-of-the-art membranes. It is also projected that ENDURION’s outcomes in the long run will contribute to an increased market share of AEMEL for the production of green hydrogen, reduced global carbon emission, a reduction of the European dependency on critical raw materials, and 20% lower levelized costs of hydrogen.